Category Archives: Uncategorized

Formation of the Newcastle University cartilage ‘SuperGroup’

 

IGM NCLWith elements of the Musculoskeletal Research Group moving from the Institute of Cellular Medicine to the Institute of Genetic Medicine we have the opportunity to create critical mass in cartilage biology, osteoarthritis and rare skeletal diseases.

Our new grouping will comprise (in alphabetical order):-

Professor Michael Briggs

http://www.ncl.ac.uk/igm/staff/profile/michael.briggs

Professor John Loughlin

http://www.ncl.ac.uk/medicalsciences/research/groups/profile/johnloughlin.html#background

Dr Kasia Pirog

http://www.ncl.ac.uk/igm/staff/profile/katarzyna.pirog

Dr Louise Reynard

http://www.ncl.ac.uk/icm/people/profile/louisereynard.html#background

Professor Drew Rowan

http://www.ncl.ac.uk/medicalsciences/research/groups/profile/drewrowan.html#research

Professor David Young

http://www.ncl.ac.uk/medicalsciences/research/groups/profile/davidyoung.html#background


Of course many of the younger research staff don’t remember the last great super group…….

cream-band-cream-38000949-460-276

Armet/Manf as a potential secreted biomarker for ER stress related diseases

MANF

Recent article published by Dr Chen and colleagues confirming that Armlet/Manf can potentially act as a diagnostic and/or prognostic biomarker in ER stress–related kidney diseases. This will help to stratify disease risk, predict disease progression, monitor treatment response and possible identify subgroups of patients who can be treated with ER stress modulators in a highly targeted manner.


This finding supports our 2103 paper using mouse models of genetic skeletal diseases Harley 2013

In this study we hypothesised that:-

“The interesting observation that Armet and Creld2 are secreted under conditions of increased ER stress suggests the possibility that they may be exploited as soluble extracellular biomarkers of ER stress-related diseases that are gene product and/or mutation specific”