You’ve all heard of the Oscars…….well we have had our own competition…..
And what will be the name of our new Cartilage ‘Super’ Group..?
we wait in anticipation….votes are cast…….decision on Wednesday…
With elements of the Musculoskeletal Research Group moving from the Institute of Cellular Medicine to the Institute of Genetic Medicine we have the opportunity to create critical mass in cartilage biology, osteoarthritis and rare skeletal diseases.
Our new grouping will comprise (in alphabetical order):-
Professor Michael Briggs
Professor John Loughlin
Dr Kasia Pirog
Dr Louise Reynard
Professor Drew Rowan
Professor David Young
Of course many of the younger research staff don’t remember the last great super group…….
Recent article published by Dr Chen and colleagues confirming that Armlet/Manf can potentially act as a diagnostic and/or prognostic biomarker in ER stress–related kidney diseases. This will help to stratify disease risk, predict disease progression, monitor treatment response and possible identify subgroups of patients who can be treated with ER stress modulators in a highly targeted manner.
This finding supports our 2103 paper using mouse models of genetic skeletal diseases
In this study we hypothesised that:-
“The interesting observation that Armet and Creld2 are secreted under conditions of increased ER stress suggests the possibility that they may be exploited as soluble extracellular biomarkers of ER stress-related diseases that are gene product and/or mutation specific”